INTRAEPIDERMAL VESICULAR AND PUSTULAR DERMAITIS
BALLOONING
| Distinctive cytologic fetures | Steel-gray, margination of chromatin | Herpes virus infections | |
| Basophilic cytoplasmic inclusions | Orf/miker's nodule | ||
| Esosinophilic cytoplasmic inclusions | Vaccinia/variola | ||
| No distinctive cytologic features | Ballooning in upper epidermis | Pellagra/ Necrolytic migratory erythema/ Acrodermatitis enteropathica/ Hartnup's disease/ Deficiencyt disease(zinc, biotin) Pachyonychia congenita Immersion blister |
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| Ballooning in midepidermis | No interface changes on volar skin or mucous membrane | Hand-foot-and-mouse disease | |
| No interface changes, confluent necrosis of keratinocytes, normal cornifeed layer, lymphocytes and neutrophils | Irritant contact dermatitis | ||
| No interface changes, individual necrotic keratinocytes, normal cornified layer, lymphocytes and neutrophils | Phototoxic dermatitis | ||
| Interface changes, individual necrotic keratinocytes, normal cornifed layer | Erythema multiforme | ||
| Interface changes, individual necrotic keratinocytes, parakeratosis | PLEVA | ||
| Interface changes, individual necrotic keratinocytes, normal cornifed layer, lymphocytes, neutrophils, and eosinophils | Fixed drug eruption, early | ||